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If asked what the most dangerous prescription drug was, what would you answer? Given the news about opioid addiction, a lot of people would likely answer something like OxyContin or fentanyl.

Nearly half of anticoagulant adverse events required a hospital stay.ISMP QUARTERWATCH – JULY 12, 2017

As it turns out, according to a recent report published by the Institute for Safe Medication Practices (ISMP) the prescription medications most likely to require an emergency room visit are anticoagulants – also known as blood thinners. These include drugs like XareltoPradaxa, and warfarin, all of which use different biochemical interactions to prevent blood from clotting.

Based on CDC data analyzed by the ISMP, there were nearly 22,000 severe injuries, including more than 3,000 deaths, reported by patients and health care workers relating to blood thinners last year. Of those, nearly half of the adverse events required a hospital stay. These are just some of the reasons that so many have taken legal action by filing Xarelto lawsuits recently, a reminder of the $650 million Pradaxa lawsuit settlementannounced by Boehringer Ingelheim in 2014.

But this only tells part of the story. Because the FDA only tracks voluntary reports, the true number of people injured by blood thinners each year is significantly higher. In fact, a different CDC study indicates that the annual number of people harmed by anticoagulants could be as much as ten times greater than voluntary reports indicate, reaching nearly a quarter of a million people.

Why Are Blood Thinners So Dangerous?

Blood thinners interrupt the blood clotting process, which is useful for treating or preventing certain medical problems that can be caused by blood clots, including strokes, pulmonary embolisms, deep vein thrombosis, and atrial fibrillation. The risk of blood clots are typically very high after certain types of surgery (such as knee or other joint replacement) and for people who tend to live a sedentary lifestyle.

The problem with blood thinners is that blood clots are sometimes a good thing. When you cut yourself, you want the blood to clot so that you stop bleeding. If blood didn’t clot, then even something as small as a tiny scratch could cause someone to eventually bleed out and die (known in the medical community as exsanguination). Thankfully, most people have blood that clots normally, so this situation does not occur.

When taking a blood thinner, however, the medication interrupts the natural formation of blood clots. Depending on the specific type of blood thinner you are taking (anticoagulant or antiplatelet), the mechanism works a little differently. But the end result is the same, in that your blood will be prevented from clotting.

The good news is that some blood thinners – like warfarin (Coumadin) – have “antidotes” to reverse their effects. If a person taking warfarin sustains an injury, a medical professional can administer some vitamin K to reverse the effects of the drug and restore the blood’s normal clotting behavior.

However, not all blood thinners have such antidotes, and others that have antidotes today did not have them until very recently. For example, the antidote for Pradaxa was only approved in 2015, so anyone taking the drug before then was at a risk of severe bleeding if they injured themselves. Individuals taking Xarelto still have that risk today, since no antidote for the anticoagulant has yet been approved by the FDA.

Minimizing the Dangers of Blood Thinners

Given that blood thinners are so dangerous, what can be done to reduce their effects? Here are a few ideas:

Always follow the drug label – This is true with any prescription, of course, but it’s especially important to follow the instructions with such a dangerous class of drugs as blood thinners. By law, pharmaceutical companies are required to provide details about potential risks and list individuals who should not take the medication.

Avoid food and drink interactions – When taking blood thinners, it’s important to avoid any foods or drinks that might interfere with the drug. This includes alcohol specifically, as well as foods rich in vitamin K, which can counteract the effects of some anticoagulants.

Talk to your doctor or pharmacist – If you don’t understand why you were given a blood thinner, talk to the prescribing physician or the pharmacist. Not sure what to ask them? Check out our list of questions to always ask your pharmacist. (The list is good for doctors, too!)

Spread awareness – Letting others know about the potential dangers of blood thinners is another way to prevent serious (and potentially deadly) side effects of anticoagulants. Given how many people are hospitalized each year due to blood thinner complications, we should be talking about it at least as much as people are talking about opioid drug use.

To be sure, blood thinners are legitimate medications with many beneficial uses for many people. However, using them safely and understanding their potential harms is an important part of making sure they remain helpful to people rather than harmful.


NEW YORKNov. 8, 2017 /PRNewswire/ — A Pennsylvania jury has been convened to hear evidence in a Xarelto lawsuitfiled on behalf of an Indiana woman who allegedly suffered serious gastrointestinal bleeding after using the novel anticoagulant for a little over a year. The case is the first to go to trial in the Philadelphia Court of Common Pleas, where more than 1,500 Xarelto bleeding claims have been centralized in a mass tort program. (Case No. 160503416)


During Monday’s opening statements, the plaintiff’s attorney asserted that the drug’s manufacturers manipulated clinical trial data and downplayed important safety information to make Xarelto appear safer and more effective than competing blood thinners, such as warfarin.

“Our Firm is representing a number of plaintiffs who are pursuing similar Xarelto claims. We will be watching the Philadelphia trial closely for any developments that could impact our clients’ cases,” says Sandy A. Liebhard, a partner at Bernstein Liebhard LLP, a nationwide law firm representing victims of defective medical devices and drugs. The Firm continues to evaluate potential Xarelto lawsuits on behalf of individuals who may have been harmed by this blood-thinning medication.

Xarelto Bleeding Allegations

Approved by the U.S. Food & Drug Administration in October 2011, Xarelto is jointly marketed by Bayer and Johnson & Johnson’s Janssen Pharmaceuticals subsidiary. The blood thinner is currently indicated for the prevention of strokes in people with atrial fibrillation; the treatment of patients suffering from deep vein thrombosis and pulmonary embolism; and the prevention of deep vein thrombosis in people undergoing hip or knee implant surgery.

Like other new-generation blood thinners, Xarelto has been touted as an improvement over decades-old warfarin. However, internal bleeding caused by warfarin can be stopped by the administration of vitamin K. There is currently no approved agent to reverse Xarelto bleeding.

Johnson & Johnson’s most recent earnings statement indicates that more than 21,000 Xarelto lawsuits have been filed in courts throughout the United States.  Plaintiffs involved in this litigation claim that the drug’s manufacturers downplayed the potential for Xarelto bleeding and wrongly promoted the drug as a superior alternative to warfarin. In addition to noting the lack of a reversal agent for Xarelto bleeding, plaintiffs take issue with the medication’s one-size-fits-all dosing regimen and dispute the defendants’ assertions that there is no need to subject Xarelto patients to routine blood monitoring.

The majority of Xarelto lawsuits are currently pending in a federal multidistrict litigation underway in the U.S. District Court, Eastern District of Louisiana, where three trials have already concluded with defense verdicts. Additional Xarelto bleeding claims have been filed in DelawareCalifornia and Missouri state courts.

Xarelto patients who allegedly experienced bleeding-related complications may be entitled to compensation for their medical bills, lost wages, pain and suffering, and more. To learn more about filing a Xarelto lawsuit, please visit Bernstein Liebhard LLP’s website, or call 800-511-5092 to arrange for a free, no obligation case review.